The Gators' offense jumped on the board early with 17 first quarter points and pulled away as they kept EMU off the scoreboard for the first time in 69 games, dating back to Sept. 27, 2008.
Meanwhile, UF snapped a seven-game losing skid to improve to 1-0 after having its originally scheduled opener last week was cancelled due to bad weather and field conditions.
Five turnovers hurt the Eagles as the offense picked up 125 yards. Brogan Roback went 5-for-10 as Eastern used three different quarterbacks on the day. EMU starting quarterback Reginald Bell was the team's leading rusher, alongside Tyler Allen, as both Eagles ran for 20 yards on the ground. All of Bell's came in the opening half.
On the defensive side of the ball, Great Ibe and Ray Tillman tallied a team-high 11 tackles. Tillman's double-digit day set a career best, tying the amount of tackles he recorded throughout the entire 2013 season.
Reigning Mid-American Conference West Special Teams Player of the Week Nathan Adams also chipped in on defense, making a tackle behind the line of scrimmage on a Florida fourth down play in the red zone.
Florida's Jeff Driskel went 31-for-45 for 248 yards, while backup quarterback Treon Harris completed a pair of passes for 148 yards.
Demarcus Robinson led the receiving corps with six catches for 123 yards, including a 70-yard touchdown reception.
The Gators chalked up 259 yards rushing, as well, for a total of 655 yards from scrimmage on the day.
Towards the end of the third quarter, transfer quarterback Rob Bolden made his EMU debut to guide the Eagles' offense.
The Eagles remain of the road next week, traveling to Norfolk, Va. to face Old Dominion University, Sept. 13. Kickoff against the Monarchs is set for 6 p.m