The hosts owned a 487-379 advantage in total offense and registered eight more first downs (23-18).
UB quarterback Joe Licata threw two touchdowns while completing 28 of 46 for 338 yards, but he also tossed two interceptions and the Bulls also had one fumble on the day.
Jordan Johnson (13/79) and Anthone Taylor (16/68) combined for 147 of Buffalo’s 149 rushing yards.
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Junior Quarterback Tyler registered his lowest attempts (20), completions (13) and yardage (90) of the season.
Licata’s 43-yard pass to Matt Weiser at 11:11 of the first period provided Buffalo with its only lead of the game. Butler scored from five yards out at 3:07 and Jackson broke loose for a 55 yard score with 12 seconds left in the first period.
Adam Mitcheson hit the first of two field goals on the day, this one from 33 yards) at 11:11 of the second period, but Nevada came right back with a 38-yarder to carry a 17-10 lead inter intermission.
Mitcheson’s 43-yard boot narrowed the gap again, but Jackson’s 10-yard run put Nevada up 24-13 at 10:25 of the third period.
Buffalo put together an eight-play, 75 yard drive that culminated with a Licata TD toss to Collin Lisa with 8:06 to play and added a two-point conversion to pull within a field goal at 24-21. The Buffalo defense forced two Wolfpack punts, but the Bulls could not get back on the board again. A final UB drive ended with Licata, faced with fourth-and-15, threw an interception.
Buffalo begins Mid-American Conference play Saturday when it hosts Bowling Green (3:30 p.m.) in a key MAC East matchup.